Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum

H Kuwayama, H Kikuchi, Y Kubohara - Biology, 2023 - mdpi.com
… differentially control stalk cell differentiation and chemotaxis. We … have at least three receptors:
DR-1D, responsible for stalk cell … to mitochondria, suggesting that DIF-1 controls stalk cell

… Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells

Y Kubohara, Y Fukunaga, H Kikuchi, H Kuwayama - Molecules, 2023 - mdpi.com
differentiation, cell death, chemotaxis, and morphogenesis, … isolated as a stalk cell
differentiation-inducing factor in D. … a mitochondrial uncoupler and can promote glucose uptake, at …

… Target of Differentiation-Inducing Factor-1 is Mitochondrial Malate Dehydrogenase for Activation of Amp-Activated Protein Kinase and Induction of Mitochondrial …

M Arioka, K Miura, R Han, K Igawa… - Available at SSRN … - papers.ssrn.com
Differentiation-inducing factor-1 (DIF-1) is a polyketide produced by Dictyostelium discoideum
… mammalian cells, at least in part by activating AMP-activated protein kinase (AMPK). In a …

Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission

T Inoue, K Miura, R Han, F Seto-Tetsuo… - Journal of …, 2023 - Elsevier
… produced by Dictyostelium discoideum that inhibits the … exhausted, unicellular cells
differentiate into multicellular fruiting … was performed using anti-HA antibody or control mouse IgG …

Calmodulin‐mediated events during the life cycle of the amoebozoan Dictyostelium discoideum

DH O'Day, S Mathavarajah, MA Myre… - Biological …, 2020 - Wiley Online Library
… characterized by chemotaxis, morphogenesis and cell differentiation. … discoideum has three
NDPK genes (mitochondrial ndkM, … role of differentiation inducing factor-1 (DIF-1) in stalk cell

Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum

P Sharma, P Jain, A Shrivastava, S Saran - … in Biogerontology: Cellular …, 2020 - Springer
… Deletion mutations in mitochondrial DNA are considered as a hallmark … discoideum is
instrumented to study chemotaxis and … Differentiation-inducing factor (DIF) triggers cell death only …

… activation of AMPK induces mitochondrial biogenesis through differential phosphorylation and abundance of mitochondrial proteins in Dictyostelium discoideum

M Heidorn-Czarna, HM Heidorn, S Fernando… - International Journal of …, 2021 - mdpi.com
… acts at a central control point in cellular energy homeostasis. … of Dictyostelium cells to
differentiation-inducing factor-1 (DIF-… There is an increasing body of evidence of the intrinsic …

[HTML][HTML] Possible involvement of the nutrient and energy sensors mtorc1 and ampk in cell fate diversification in a non-metazoan organism

JD Gross, CJ Pears - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
… We describe evidence suggesting that overexpressing … the prespore pathways of cell
differentiation may depend on the … in strains with defective mitochondrial function, which is thought …

Calmodulin and Calmodulin Binding Proteins in Dictyostelium: A Primer

DH O'Day, RJ Taylor, MA Myre - International journal of molecular …, 2020 - mdpi.com
… This is often performed in parallel with a control scrambled … , cAMP oscillations, chemotaxis,
stalk cell differentiation, spore … verified and there is no evidence that it works in concert with …

In Vivo Assembly of a Dictyostelium Lamin Mutant Induced by Light, Mechanical Stress, and pH

M Grafe, P Hofmann, P Batsios, I Meyer, R Gräf - Cells, 2020 - mdpi.com
… that the last activation step, ie, the positive control, … evidence leads to mitochondria. Already
in 1978, Manabe and Poff described blue light sensitivity (photoreduction) of Dictyostelium